abstract：:The chemokine C receptor 7 (CCR7) is a G-protein-coupled heptahelical receptor (GPCR) that is expressed on a wide variety of cells including memory T cells, B cells, mature dendritic cells, and cancer cells. Activated by its ligands CCL19 or CCL21, CCR7 plays a major role in metastasis of cancer cells. Recent studies ...

journal_title：Human immunology

authors： Al Akoum C,Akl I,Rouas R,Fayyad-Kazan M,Falha L,Renno T,Burny A,Lewalle P,Fayyad-Kazan H,Badran B

更新日期：2015-05-01 00:00:00

abstract：:Recent data puts WNT signaling pathway in a pivotal role in regulating pancreas development as well as islet function, insulin production and secretion. The key effectors in the WNT signaling pathway are low-density lipoprotein receptor-related protein 5 (LRP5), transcription factor 7-like 2 (TCF7L2), and downstream-r...

journal_title：Human immunology

authors： Wang J,Yan G,Zhang J,Gao K,Zhang M,Li L,Wang Y,Wang Q,Zhai Y,You H,Ren Y,Wang B,Hu D

更新日期：2015-05-01 00:00:00

abstract：:Polymorphisms present in the TNF promoter region has shown to influence the gene transcription. Leprosy displays different clinical manifestations according to the immune responses of the individual infected with Mycobacterium leprae. In this study, we evaluated the single nucleotide polymorphisms (SNPs) -238 G/A (rs3...

journal_title：Human immunology

authors： Silva GA,Ramasawmy R,Boechat AL,Morais AC,Carvalho BK,Sousa KB,Souza VC,Cunha MG,Barletta-Naveca RH,Santos MP,Naveca FG

更新日期：2015-03-01 00:00:00

abstract：:Basophils are the rare granulocytes and play an important role in the polarization of Th2 responses and protection against helminth parasites. In addition, basophils contribute to the pathogenesis of several diseases such as asthma, chronic allergy and lupus. Notably, Th17 cells are also implicated in the pathogenesis...

journal_title：Human immunology

authors： Sharma M,Stephen-Victor E,Poncet P,Kaveri SV,Bayry J

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:We explored whether cytotoxic T lymphocyte antigen-4 (CTLA-4) rs5742909, CD226 rs763361, FAS rs1800682, and FASL rs763110 polymorphisms are associated with rheumatoid arthritis (RA). METHODS:We performed a meta-analysis on the association between the four gene polymorphisms and RA. RESULTS:Nineteen studies ...

journal_title：Human immunology

authors： Lee YH,Bae SC,Song GG

更新日期：2015-03-01 00:00:00

abstract：:The Human Leukocyte Antigen-G has immunomodulatory function and its expression has been associated with several diseases. In our study we analyzed HLA-G polymorphisms in order to evaluate their possible association with susceptibility to celiac disease development. A total of 420 celiac patients and 509 controls were ...

journal_title：Human immunology

authors： Catamo E,Zupin L,Segat L,Celsi F,Crovella S

更新日期：2015-01-01 00:00:00

abstract：:The association of rs12979860 and rs8099917 single nucleotide polymorphisms (SNPs) near IL28B with sustained virological response (SVR) in hepatic allograft recipients undergoing treatment with PEGylated interferon (PEG-IFN) plus ribavirin (RBV) for recurrent hepatitis C virus (HCV) infection remains inconclusive. We ...

journal_title：Human immunology

authors： Zhang L,Lu Q,Yang Z,Wang X,Cai L,Liu X,Liao R,Yang X,Chen Y,Yang Z

更新日期：2014-12-01 00:00:00

abstract：:Hepatitis E virus (HEV) causes high mortality among pregnant women. Pathogenesis of HEV, especially during pregnancy, is poorly understood. Our aim was to assess the role of Toll-like-receptors (TLRs) in hepatitis E patients with pregnancy (Antenatal care, ANC) or without pregnancy (non-ANC). The patient categories in...

journal_title：Human immunology

authors： Arya RP,Arankalle VA

更新日期：2014-12-01 00:00:00

abstract：:Two groups of residents in an endemic area of Leishmania major infection in Iran with positive leishmanin skin tests who were either asymptomatic or had healed cutaneous leishmaniasis lesions were compared with respect to their T helper responses. The percentages of regulatory T cells (Treg; CD4(+)CD25(high) FoxP3(+))...

journal_title：Human immunology

authors： Bahrami F,Darabi H,Riazi-Rad F,Khaze V,Ajdary S,Alimohammadian MH

更新日期：2014-10-01 00:00:00

abstract：:Beta-1,4-galactosyltransferase I (β-1,4-GalT-I) mediates several biological mechanisms as a key enzyme in glycobiology, but the role of β-1,4-GalT-I in immune system remains unclear. We conducted experiments to investigate whether β-1,4-GalT-I is participating in the activation of Jurkat T cell and intercellular conta...

journal_title：Human immunology

authors： Sun X,Wu Y,Wang Y,Xue Q,Cheng X,Zhang G,Zhu Y,Wang X

更新日期：2014-10-01 00:00:00

abstract：:Gene copy number variation (CNV) of the CC Chemokine ligand 3-Like-1 (CCL3L1) gene located on chromosome 17q12 has been associated with many diseases, including viral infections and autoimmune diseases. High sequence homology between CCL3L1 and three other related genes within the same cluster, CCL3, CCL3L2, and CCL3L...

journal_title：Human immunology

authors： Perry RT,Nyaku MK,Aissani B,Shrestha S

更新日期：2014-08-01 00:00:00

abstract：:This study aimed at evaluating the functional activation and activating receptors expression on resting, short- and long-term NK and NK-like T cells from blood of ovarian neoplasia patients. Blood from patients with adnexal benign alterations (n = 10) and ovarian cancer (grade I-IV n = 14) were collected after signed ...

journal_title：Human immunology

authors： da Silva RF,Petta CA,Derchain SF,Alici E,Guimarães F

更新日期：2014-08-01 00:00:00

abstract：:In our earlier studies, single nucleotide polymorphisms (SNPs) associated with anti-inflammatory cytokines were found to influence risk for breast cancer in western Indian women. Analysis of Interleukin 6 (IL-6) -174G>C polymorphism in this cohort (patients = 182; controls = 236) suggested a protective role for IL-6 -...

journal_title：Human immunology

authors： Joshi N,Kannan S,Kotian N,Bhat S,Kale M,Hake S

更新日期：2014-08-01 00:00:00

abstract：:Killer immunoglobulin-like receptors (KIRs) regulate function of NK cells and subsets of T cells. HLA class I molecules are ligands for inhibitory KIRs while specificity of activating KIRs is mainly unknown. Both KIR and HLA genotypes are highly polymorphic. In this study we analyzed associations of KIR and KIR ligand...

journal_title：Human immunology

authors： Giebel S,Boratyn-Nowicka A,Karabon L,Jedynak A,Pamula-Pilat J,Tecza K,Kula D,Kowal M,Frydecka I,Grzybowska E

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to explore whether the cytotoxic T lymphocyte associated antigen-4 (CTLA-4) polymorphisms are associated with susceptibility to ulcerative colitis (UC) and Crohn's disease (CD). METHODS:The authors conducted a meta-analysis on associations between CTLA-4 +49 A/G, -318 C/T, CT60 A/G ...

journal_title：Human immunology

authors： Lee YH,Kim JH,Seo YH,Choi SJ,Ji JD,Song GG

更新日期：2014-05-01 00:00:00

abstract：:rs151290 in KCNQ1 and rs972283 in KLF14 have been evaluated in terms of risk of type 2 diabetes mellitus (T2DM), but the results are inconsistent. We performed an meta-analysis to assess the contributions of rs151290 in KCNQ1 and rs972283 in KLF14 to risk of T2DM. We searched the worldwide literature published from 20...

journal_title：Human immunology

authors： Wang J,Zhang J,Shen J,Hu D,Yan G,Liu X,Xu X,Pei L,Li Y,Sun C

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:IL-10 is a potent anti-inflammatory cytokine that plays important roles in the pathogenesis of Behçet's disease (BD). Two genome-wide association studies have identified IL10 as a potential risk factor for BD. Here, we investigated the association between IL10 polymorphisms and BD in Chinese Han. METHODS:407...

journal_title：Human immunology

authors： Wu Z,Zheng W,Xu J,Sun F,Chen H,Li P,Chen S,Shen M,Zhang W,You X,Wu Q,Zhang F,Li Y

更新日期：2014-03-01 00:00:00

abstract：:LMP2/LMP7 gene (LMP, low molecular mass protein) perform a critical role in the foreign antigen processing via the major histocompatibility complex-I (MHC-I) complex CD8(+) cytotoxic T lymphocytes (CTL) pathway. This study was designed to investigate whether the sequence variants in LMP2/LMP7 gene would increase the r...

journal_title：Human immunology

authors： Song L,Ma N,Han L,Yan H,Yan B,Yuan Z,Cao B

更新日期：2014-03-01 00:00:00

abstract：:The aim of this study was to examine the role of single nucleotide polymorphisms (SNPs) and haplotypes of the tumor necrosis factor ligand superfamily member 15 (TNFSF15) gene in Hungarians with psoriasis and psoriatic arthritis. A case-control study was performed, and five TNFSF15 SNPs (rs3810936, rs6478108, rs647810...

journal_title：Human immunology

authors： Képíró L,Széll M,Kovács L,Keszthelyi P,Kemény L,Gyulai R

更新日期：2014-02-01 00:00:00

abstract：:Recent evidences have shown that several host genetic factors influence susceptibility or protection to hepatitis C virus (HCV) infection. There are controversial data regarding the associations of human leukocyte antigens (HLA) and the clearance or progression of HCV. The aim of this study was to investigate whether ...

journal_title：Human immunology

authors： Grimaldi V,Sommese L,Picascia A,Casamassimi A,Cacciatore F,Renda A,De Rosa P,Montesano ML,Sabia C,Fiorito C,De Iorio G,Napoli C

更新日期：2013-12-01 00:00:00

abstract：:CTLA-4 inhibitory molecule plays an important role in regulating T cell activation. It is considered a crucial element in keeping the immune balance and has been implicated in cancer, autoimmunity and transplantation immunology. Inconsistent observations are reported regarding its association with hematopoietic stem c...

journal_title：Human immunology

authors： Mossallam GI,Samra MA

更新日期：2013-12-01 00:00:00

abstract：:Macrophages can be polarized into classically (CAM) or alternatively (AAM) activated macrophages with IFN-γ or IL-4, respectively. CAM are associated with type 1 immune responses and are implicated in autoimmunity; AAM are associated with type 2 responses and are implicated in allergic diseases. An impediment in inves...

journal_title：Human immunology

authors： El Fiky A,Perreault R,McGinnis GJ,Rabin RL

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Tumour necrosis factor-alpha (TNF-alpha) has been implicated in the pathogenesis of generalized aggressive periodontitis (AgP) and chronic periodontitis (CP). The objective of the present study was to evaluate the association of four TNF-alpha gene polymorphisms (-1031T/C, -857C/T, -308G/A and -238G/A) with ...

journal_title：Human immunology

authors： Yang W,Jia Y,Wu H

更新日期：2013-12-01 00:00:00

abstract：:It has been known for some time that transplant recipients may have antibodies to endothelial cells which are not detected on lymphocytes. However, little progress has been made in the analysis of these endothelial antigens. In the present experiments we have attempted to characterize endothelial cell surface antigens...

journal_title：Human immunology

authors： Qin Z,Zou Y,Lavingia B,Stastny P

更新日期：2013-11-01 00:00:00

abstract：:Sarcoidosis is a multisystem granulomatous disorder of unknown etiology. Hereditary etiology has been proposed as a cause of the sarcoidosis, and some Human Leucocyte Antigen (HLA) alleles have been related to the diagnosis or severity of the disease. Löfgren's syndrome has been linked to patients with the DRB1*03 all...

journal_title：Human immunology

authors： da Costa CH,Silva VL,Fabricio-Silva GM,Usnayo M,Rufino R,Porto LC

更新日期：2013-10-01 00:00:00

abstract：AIMS:We studied the influence of IL-4 gene polymorphisms on the IPF phenotype, i.e., extent of radiological changes (HRCT interstitial (IS) and alveolar (AS) score) and histopathological markers from lung biopsies. PATIENTS AND METHODS:46 IPF patients underwent genotyping, 43 of them had HRCT and 14 patients had a sur...

journal_title：Human immunology

authors： Vasakova M,Sterclova M,Matej R,Olejar T,Kolesar L,Skibova J,Striz I

更新日期：2013-10-01 00:00:00

abstract：:We have calculated six-locus high resolution HLA A∼C∼B∼DRB3/4/5∼DRB1∼DQB1 haplotype frequencies using all Be The Match(®) Registry volunteer donors typed by DNA methods at recruitment. Mixed resolution HLA typing data was inputted to a modified expectation-maximization (EM) algorithm in the form of genotype lists gene...

journal_title：Human immunology

authors： Gragert L,Madbouly A,Freeman J,Maiers M

更新日期：2013-10-01 00:00:00

abstract：:This study addresses the reactivity patterns of human cytotoxic HLA class I epitope-specific monoclonal antibodies in Ig-binding and complement component C1q-binding Luminex assays in comparison with complement-dependent lymphocytotoxicity data reported at the 13th International HLA Workshop. Some monoclonal antibodie...

journal_title：Human immunology

authors： Duquesnoy RJ,Marrari M,Jelenik L,Zeevi A,Claas FH,Mulder A

更新日期：2013-10-01 00:00:00

abstract：:Dendritic cells (DCs) play an important role in inducing immune tolerance. Inhibitory receptors, such as ILT2/CD85j, are involved in the tolerogenic effect of DCs and previous studies have indicated the important role of these receptors on the pathogenesis of autoimmune diseases. The aim of this study was to evaluate ...

journal_title：Human immunology

authors： Monsiváis-Urenda A,Gómez-Martin D,Santana-de-Anda K,Cruz-Martínez J,Alcocer-Varela J,González-Amaro R

更新日期：2013-09-01 00:00:00

abstract：:The strategy of studying the putative role of RA susceptibility genetic factors in the development of juvenile idiopathic arthritis (JIA), an autoimmune disease characterized by persistent chronic arthritis, has been proven highly successful so far. Moreover, accumulated evidence indicates that an ethnic heterogeneity...

journal_title：Human immunology

authors： Dimopoulou DG,Zervou MI,Trachana M,Myrthianou E,Pratsidou-Gertsi P,Kardassis D,Garyfallos A,Goulielmos GN

更新日期：2013-09-01 00:00:00

abstract：:Myasthenia gravis (MG) is a neuromuscular disorder characterized by fatigability and weakness of striated muscles. Its association with HLA molecules is well known and varies depending on age, sex and the ethnicity of the patients. A case-control study was performed in 61 Cuban patients and 81 controls using polymeras...

journal_title：Human immunology

authors： Sylvia T,Samuel M,Luis G,Zuzet M

更新日期：2013-08-01 00:00:00

abstract：:Signal transducer and activator of transcription 4 (STAT4) has been recently identified as a susceptibility gene for multiple autoimmune diseases. Here we performed a comprehensive analysis of the association between STAT4 and several different autoimmune disorders to identify potential common inflammatory principles ...

journal_title：Human immunology

authors： Zheng J,Yin J,Huang R,Petersen F,Yu X

更新日期：2013-08-01 00:00:00

abstract：:Despite the large local donor registries, for some Israeli patients an HLA-matched unrelated donor cannot be identified within a favorable time period. This study aims to retrospectively analyze donor search processes in our transplantation center in order to provide a basis to enhance the efficacy of these procedures...

journal_title：Human immunology

authors： Israeli M,Yeshurun M,Stein J,Ram R,Shpilberg O,Levi CL,Klein T

更新日期：2013-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a primary malignant tumor of the liver. We evaluated the association of alleles and genotypes of polymorphisms of IL-18 (-607C/A and -137G/C), IFN-γ (+874T/A) and TNF-α (-238G/A and -308G/A) with the risk and severity of HCC. One-hundred-and-twelve patients with HCC and 202 healthy co...

journal_title：Human immunology

authors： Teixeira AC,Mendes CT Jr,Marano LA,Deghaide NH,Secaf M,Elias J Jr,Muglia V,Donadi EA,Martinelli AL

更新日期：2013-08-01 00:00:00

abstract：:Genomic aberrations in the CREBBP (CREB-binding protein - CREBBP or CBP) gene such as point mutations, small insertions or exonic copy number changes are usually associated with Rubinstein-Taybi syndrome (RTs). In this study, the disruption of the CREBBP gene on chromosome 16p13.3, as revealed by CGH-array and FISH, s...

journal_title：Human immunology

authors： Torres LC,Kulikowski LD,Ramos PL,Sugayama SM,Moreira-Filho CA,Carneiro-Sampaio M

更新日期：2013-08-01 00:00:00

abstract：:Many studies have shown that Human leukocyte antigen (HLA) class I alleles are associated with the development of various cancers. However, its role in hepatocellular carcinoma (HCC) is still unknown. To investigate whether HLA class I allelic polymorphism is related to the development of hepatitis B virus(HBV)-associ...

journal_title：Human immunology

authors： Pan N,Chen K,Qiu J,Sun H,Xu J,Miao F,Shi Q,Jiang W,Jin H,He Y,Xie W,Zhang J

更新日期：2013-06-01 00:00:00

abstract：:Several complement regulatory proteins exist on self-cells to prevent damage by the serum complement system. In the present study, we aimed to perform quantitative analysis of membrane-bound complement regulators, CR1 (CD35), MCP (CD46), DAF (CD55), and MIRL (CD59), on peripheral blood neutrophils, monocytes, and lymp...

journal_title：Human immunology

authors： Nuutila J,Jalava-Karvinen P,Hohenthal U,Kotilainen P,Pelliniemi TT,Nikoskelainen J,Lilius EM

更新日期：2013-05-01 00:00:00

abstract：:An independent pool of 16 incompatible live donor-recipient pairs registered at the Vienna transplant unit was applied to test whether virtual crossmatch allocation used in the Australian kidney paired donation (KPD) program reliably predicts negative crossmatches. High resolution HLA data were entered into the comput...

journal_title：Human immunology

authors： Böhmig GA,Fidler S,Christiansen FT,Fischer G,Ferrari P

更新日期：2013-05-01 00:00:00

abstract：:Plants are widely accepted as a general platform for the large-scale production of recombinant proteins, which has been demonstrated by the successful expression of various exogenous proteins. Using plants as a bioreactor for mass production of target proteins for vaccines is thought to show the most potential. This s...

journal_title：Human immunology

authors： Li C,Jiang Y,Guo W,Liu Z

更新日期：2013-05-01 00:00:00

abstract：:HLA-G molecules seem to have a protective effect for the semi-allogeneic fetus by mother immunosuppression. Also, pregnancy pathologies have been associated to HLA-G(∗)01:05N "null allele". In addition, other general regulatory immune functions have been associated to HLA-G in infections, tumors and autoimmunity. Thus...

journal_title：Human immunology

authors： Arnaiz-Villena A,Enriquez-de-Salamanca M,Areces C,Alonso-Rubio J,Abd-El-Fatah-Khalil S,Fernandez-Honrado M,Rey D

更新日期：2013-04-01 00:00:00